the p110δ structure: mechanisms for selectivity and potency of new Pi(3)K inhibitors
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cover caption Nat. Chem. Biol. 6 (2010); published online 12 February 2010; corrected after print 18 March 2010 In the version of this cover caption initially published, Sigrid Hart’s name was misspelled. The error has been corrected in the HTML and PDF versions of the cover caption. erratum the p110δ structure: mechanisms for selectivity and potency of new Pi(3)K inhibitors Alex Berndt, Simon Miller, Olusegun Williams, Daniel D Le, Benjamin T Houseman, Joseph I Pacold, Fabrice Gorrec, Wai-Ching Hon, Pingda Ren, Yi Liu, Christian Rommel, Pascale Gaillard, Thomas Rückle, Matthias K Schwarz, Kevan M Shokat, Jeffrey P Shaw & Roger L Williams Nat. Chem. Biol. 6, 117–124 (2010); published online 10 January 2010; corrected after print 12 February 2010 and 2 March 2010 In the version of this article initially published, the structure of p110δ in complex with the inhibitor IC87114 was refined with an incorrect inhibitor structure (original Protein Data Bank accession code 2WXE). The structure has now been refined with the correct inhibitor structure and redeposited in the PDB with accession code 2X38. The structural image in Fig. 2a and the PDB accession code in the Methods section of the paper have been corrected in the HTML and PDF versions of the article. corrigendum
منابع مشابه
The p110δ crystal structure uncovers mechanisms for selectivity and potency of novel PI3K inhibitors
Deregulation of the phosphoinositide-3-OH kinase (PI(3)K) pathway has been implicated in numerous pathologies including cancer, diabetes, thrombosis, rheumatoid arthritis and asthma. Recently, small-molecule and ATP-competitive PI(3)K inhibitors with a wide range of selectivities have entered clinical development. In order to understand the mechanisms underlying the isoform selectivity of these...
متن کاملThe p110delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.
cover caption Nat. Chem. Biol. 6 (2010); published online 12 February 2010; corrected after print 18 March 2010 In the version of this cover caption initially published, Sigrid Hart’s name was misspelled. The error has been corrected in the HTML and PDF versions of the cover caption. erratum the p110δ structure: mechanisms for selectivity and potency of new Pi(3)K inhibitors Alex Berndt, Simon ...
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تاریخ انتشار 2010